Description
Dioxin is a teratogen that exerts its effects through the arylhydrocarbon receptor in conjunction with the receptor s binding partner, arylhydrocarbon receptor nuclear translocator. This protein represses signal transduction by the arylhydrocarbon receptor by competing with the arylhydrocarbon receptor nuclear translocator for binding to the arylhydrocarbon receptor. Expression of the repressor is stimulated by the receptor
translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor kappa-B